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nanoString GeoMx™ Digital Spatial Profiler
nanoString GeoMx™ Digital Spatial Profiler(DSP)
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nanoString GeoMx™

Digital Spatial Profiler



The Spatial Biology Solution™

Whether you are a discovery or translational researcher, the GeoMx DSP is the most flexible spatial solution designed to conform to your ever-changing research needs.

 

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GeoMx Digital Spatial Profiler: Any Target

GeoMx Digital Spatial Profiler: Any Region

GeoMx Digital Spatial Profiler: Any Sample


Any TARGET

Explore biology with more targets (>20,000) and more analytes (RNA & Protein) to get to your publishable discovery data faster.

Explore Spatial Biology with more targets and more analytes MSC_MK2412_GeoMx_Protein reagents.png


Any REGION

Experience automated or customized region of interest (ROI) selection based on the true biology of the sample. From tumor and microenvironment down to the single cell resolution, flexible selection allows you to get to answers faster.

Discover true spatial genomics from tumor and microenvironment


Any SAMPLE

Expand your research scope and/or collaborations to access more sample types. From FFPE and Fresh Frozen to the most challenging sample types, your research is not limited by type of sample leading to broader discovery and faster data.

Study spatial transcriptomics from any sample ranging from FFPE to fresh frozen.Study spatial transcriptomics from any sample ranging from FFPE to fresh frozen.Study spatial transcriptomics from any sample ranging from FFPE to fresh frozen.


Robust, Automated Workflow

GeoMx Digital Spatial Profiler: Robust Automated Workflow


Explore Your Data

The GeoMx DSP data center provides end-to-end software solution from image acquisition, region of interest selection to a fully integrated data analysis experience.

View the end-to-end spatial gene expression solution

Explore-the-Data.jpg

 

Spatial Profiling

Biology based segmentation enables near 100% cellularity

Canonical driver and immuno-oncology genes are expressed by both Tumor and Microenvironment. Only with segmented profling can we attribute their expression to either cell type.GeoMx-Spatial-Profiling.jpg

 

Biomarker Discovery

Spatial resolution of Immune Response within the Microenvironment

segmentation-diagram.jpg

Segmentation allows for the identification of biomarkers related to the location and signaling of immune cells, which have the potential to unveil targets for therapeutic combinations in MSI and MSS CRC tumors.

GeoMx-Volcano-Plot_1.jpg

GeoMx-Volcano-Plot_2.jpg


Pathway Analysis

Spatial mapping of pathway activation and signaling.
 

Pathway signaling within tissue compartments:

Pathway-Analysis.jpg

 

Explore pathway signaling across complex tissue structures and tumor boundaries:

Flexible content designed to fit a range of applications and plex needs

GeoMx Protein and RNA assays allow you to profile up to 96 targets with nCounter readout or 10’s-100’s of protein targets or >1,800 RNA targets with NGS readout from a single FFPE or fresh frozen slide with Digital Spatial Profiling. GeoMx Assays are pre-validated and modular to provide flexibility and support a range of research needs. For protein, select one 20-plex core and add 10-plex modules to analyze expression of your proteins of interest. Additionally, antibodies can be customized for use with GeoMx® DSP through the Protein Barcoding Service and from Abcam. For RNA, select a core panel with the option to add custom user defined content.

Available content covers immunology, immuno-oncology, neurodegeneration, and neuroinflammation with a rapidly growing pipeline.

Request current assay content list >>
See below for detailed assay information.

 

GeoMx® Protein Assays for nCounter

Designed to profile up to 96 protein targets simultaneously with spatial resolution using the nCounter® platform.

MK1461_Updated-for-Web-Protein_Assay_CoreModules_FINAL.png

Immuno-Oncology and Immunology

The Immune Cell Profiling Core contains 18 targets for broad cell profiling of human samples (17 targets for mouse) and includes necessary controls for all GeoMx DSP experiments. Up to six 10-plex modules plus 10 custom targets can be added to select the content most relevant to your human and mouse research.

Neuroscience

The Neural Cell Profiling Core contains 20 targets designed for broad cell profiling of human samples (19 targets for mouse) and includes necessary controls for all GeoMx DSP experiments. Up to six 10-plex modules plus 10 custom targets can be added to select the content most relevant to your human and mouse research.

 

GeoMx® RNA Assays for nCounter

The 84-plex Immune Pathways panel profiles RNA targets simultaneously, with the option to add up to 10 custom RNA probes, with spatial resolution using the nCounter® platform.

  nCounter Readout
Protein RNA
Cores Immune Cell Profiling (18 plex human, 17 plex mouse) Neural Cell Profiling (20 plex human, 19 plex mouse) Immune Pathways (84 plex)
Modules (~10-plex) Immune Activation Status
Immune Cell Typing
IO Drug Target
Pan-Tumor
Cell Death
P13K/AKT Signaling
MAPK Signaling
Alzheimer's Pathology
Alzheimer's Pathology Extended
Parkinson's Pathology
Autophagy
Glial Cell Subtyping
N/A
Custom Yes Yes Yes

 

GeoMx® Protein Assays for NGS

Designed to profile 10’s-100’s of protein targets simultaneously with spatial resolution using NGS platforms and pipelines. Run the 4-plex GeoMx Human Protein Core for NGS, which includes CD45, Ki-67, B2M, CD31, and the necessary controls for GeoMx DSP experiments, with any selection of 10-plex modules.

 

GeoMx® RNA Assays for NGS

Designed to profile up to over 1,800 RNA targets simultaneously with the GeoMx Cancer Transcriptome Atlas or over 18,000 genes with the GeoMx Whole Transcriptome Atlas.

  NGS Readout
Protein RNA
Cores GeoMx Human Protein Core for NGS (4 plex) GeoMx Cancer Transcriptome Atlas (>1,800 plex)
GeoMx Whole Transcriptome Atlas (>18,000 plex)
Modules (~10-plex) Immune Cell Typing*
IO Drug Target*
Immune Activation Status*
Pan-Tumor*
Myeloid*
Cell Death**
P13K/AKT Signaling**
MAPK Signaling**
Neural Cell Profiling**
AD Pathology**
PD Pathology**
N/A
Custom Yes Yes

* Launching Q4 2020, pre-ordering available
** Launching Q1 2021



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